Supplementary Materials

Supplementary Materials for:

Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome

Risa Kashima, Patrick L. Redmond, Prajakta Ghatpande, Sougata Roy, Thomas B. Kornberg, Thomas Hanke, Stefan Knapp, Giorgio Lagna, Akiko Hata*

*Corresponding author. Email: akiko.hata{at}ucsf.edu

This PDF file includes:

  • Text S1. LarvaTrack algorithm.
  • Text S2. Synthesis of TH263.
  • Fig. S1. Allosteric antagonists of LIMK1/2 reverse the locomotion phenotype in
    dFMR1Î"113/+ larvae.
  • Fig. S2. Administration of LIMK-i ameliorates neuromorphological abnormalities in
    a mouse model of FXS.
  • Fig. S3. Homozygous dFMR1Î"50 and dFMR13 mutants exhibit a frequently turning
    phenotype.
  • Fig. S4. The object tracker initialization and procedure at f = 0 and f = 1.
  • Reference (56)

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Citation: R. Kashima, P. L. Redmond, P. Ghatpande, S. Roy, T. B. Kornberg, T. Hanke, S. Knapp, G. Lagna, A. Hata, Hyperactive locomotion in a Drosophila model is a functional readout for the synaptic abnormalities underlying fragile X syndrome. Sci. Signal. 10, eaai8133 (2017).

© 2017 American Association for the Advancement of Science