Supplementary Materials

Supplementary Materials for:

Androgen receptor inhibitor–induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

Likun Li, Styliani Karanika, Guang Yang, Jiangxiang Wang, Sanghee Park, Bradley M. Broom, Ganiraju C. Manyam, Wenhui Wu, Yong Luo, Spyridon Basourakos, Jian H. Song, Gary E. Gallick, Theodoros Karantanos, Dimitrios Korentzelos, Abul Kalam Azad, Jeri Kim, Paul G. Corn, Ana M. Aparicio, Christopher J. Logothetis, Particia Troncoso, Timothy Heffernan, Carlo Toniatti, Hyun-Sung Lee, Ju-Seog Lee, Xuemei Zuo, Wenjun Chang, Jianhua Yin, Timothy C. Thompson*

*Corresponding author. Email: timthomp{at}mdanderson.org

This PDF file includes:

  • Fig. S1. Sequence and copy number variation analysis using T200 platform.
  • Fig. S2. Titration of ENZ and OLA for colony assays.
  • Legends for tables S1 to S3
  • Table S4. Primers and probes for qRT-PCR.
  • Table S5. siRNA sources and sequences.

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Technical Details

Format: Adobe Acrobat PDF

Size: 494 KB

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Determination of synergy.
  • Table S2 (Microsoft Excel format). Expression of proapoptotic genes.
  • Table S3 (Microsoft Excel format). Expression of antiapoptotic genes.

[Download Tables S1 to S3]


Citation: L. Li, S. Karanika, G. Yang, J. Wang, S. Park, B. M. Broom, G. C. Manyam, W. Wu, Y. Luo, S. Basourakos, J. H. Song, G. E. Gallick, T. Karantanos, D. Korentzelos, A. K. Azad, J. Kim, P. G. Corn, A. M. Aparicio, C. J. Logothetis, P. Troncoso, T. Heffernan, C. Toniatti, H.-S. Lee, J.-S. Lee, X. Zuo, W. Chang, J. Yin, T. C. Thompson, Androgen receptor inhibitor–induced "BRCAness" and PARP inhibition are synthetically lethal for castration-resistant prostate cancer. Sci. Signal. 10, eaam7479 (2017).

© 2017 American Association for the Advancement of Science