Supplementary Materials

Supplementary Materials for:

Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells

Jeffrey J. Rodvold, Kevin T. Chiu, Nobuhiko Hiramatsu, Julia K. Nussbacher, Valentina Galimberti, Navin R. Mahadevan, Karl Willert, Jonathan H. Lin, Maurizio Zanetti*

*Corresponding author. Email: mzanetti{at}ucsd.edu

This PDF file includes:

  • Fig. S1. TERS transmission and reception occur among various human cancer cell lines.
  • Fig. S2. Nutrient-starved TERS-primed cells have increased viability during nutrient deprivation.
  • Fig. S3. Bortezomib does not affect UPR transcription between vehicle- and TERS-primed cells but is less cytotoxic to TERS-primed cells.
  • Fig. S4. TERS-primed LNCaP cells are protected from paclitaxel cytotoxicity.
  • Fig. S5. TERS CM promotes abundance in β-catenin.
  • Fig. S6. Validation of PC3.TOP reporter system.
  • Fig. S7. MEF KO cells have selective sensitivity to TERS.
  • Fig. S8. Population fitness of TERS-primed cells.
  • Fig. S9. Histology analysis of TC1 vehicle- and TERS-primed tumors.

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Citation: J. J. Rodvold, K. T. Chiu, N. Hiramatsu, J. K. Nussbacher, V. Galimberti, N. R. Mahadevan, K. Willert, J. H. Lin, M. Zanetti, Intercellular transmission of the unfolded protein response promotes survival and drug resistance in cancer cells. Sci. Signal. 10, eaah7177 (2017).

© 2017 American Association for the Advancement of Science