Supplementary Materials

Supplementary Materials for:

IRE1α promotes viral infection by conferring resistance to apoptosis

Susan L. Fink,* Teshika R. Jayewickreme, Ryan D. Molony, Takao Iwawaki, Charles S. Landis, Brett D. Lindenbach, Akiko Iwasaki*

*Corresponding author. Email: akiko.iwasaki{at}yale.edu (A.I.); sfink{at}uw.edu (S.L.F.)

This PDF file includes:

  • Fig. S1. Increased IFN and ISG expression during VSV infection of Xbp1-deficient MEFs.
  • Fig. S2. Knockdown of Xbp1 with siRNA mimics Xbp1 deficiency, and reconstitution with Xbp1 reverses resistance to cell death.
  • Fig. S3. Xbp1 deficiency does not increase susceptibility to a noncytotoxic virus and mimics BCL2 overexpression.
  • Fig. S4. Resistance to virally induced apoptosis in Xbp1-deficient cells is independent of Beclin 1.
  • Fig. S5. Death of VSV- and HSV-infected cells does not require Chop.
  • Fig. S6. VSV infection does not activate the UPR.
  • Fig. S7. The resistance of Xbp1-deficient cells to apoptosis results from the activation of IRE1α.
  • Fig. S8. The miRNA miR-125a regulates resistance to apoptosis.

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Citation: S. L. Fink, T. R. Jayewickreme, R. D. Molony, T. Iwawaki, C. S. Landis, B. D. Lindenbach, A. Iwasaki, IRE1α promotes viral infection by conferring resistance to apoptosis. Sci. Signal. 10, eaai7814 (2017).

© 2017 American Association for the Advancement of Science