Supplementary Materials

Supplementary Materials for:

Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors

Bin Li, Darren Orton, Leif R. Neitzel, Luisana Astudillo, Chen Shen, Jun Long, Xi Chen, Kellye C. Kirkbride, Thomas Doundoulakis, Marcy L. Guerra, Julia Zaias, Dennis Liang Fei, Jezabel Rodriguez-Blanco, Curtis Thorne, Zhiqiang Wang, Ke Jin, Dao M. Nguyen, Laurence R. Sands, Floriano Marchetti, Maria T. Abreu, Melanie H. Cobb, Anthony J. Capobianco, Ethan Lee, David J. Robbins*

*Corresponding author. Email: drobbins{at}med.miami.edu

This PDF file includes:

  • Fig. S1. SSTC3 inhibits WNT signaling via CK1α.
  • Fig. S2. SSTC3 attenuates the viability of cells dependent on WNT activity.
  • Fig. S3. A structural analog of SSTC3, SSTC111, does not inhibit WNT biomarkers in CRC cells.
  • Fig. S4. SSTC3 treatment decreases tumor cell density in CRC xenografts.
  • Fig. S5. SSTC3 has limited on-target GI toxicity in mice.
  • Fig. S6. Decreased abundance of CK1α sensitizes cells to SSTC3.

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Citation: B. Li, D. Orton, L. R. Neitzel, L. Astudillo, C. Shen, J. Long, X. Chen, K. C. Kirkbride, T. Doundoulakis, M. L. Guerra, J. Zaias, D. L. Fei, J. Rodriguez-Blanco, C. Thorne, Z. Wang, K. Jin, D. M. Nguyen, L. R. Sands, F. Marchetti, M. T. Abreu, M. H. Cobb, A. J. Capobianco, E. Lee, D. J. Robbins, Differential abundance of CK1a provides selectivity for pharmacological CK1a activators to target WNT-dependent tumors. Sci. Signal. 10, eaak9916 (2017).

© 2017 American Association for the Advancement of Science