Supplementary Materials

Supplementary Materials for:

The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ

Tzu-Chieh Chen, Daniel I. Benjamin, Taiyi Kuo, Rebecca A. Lee, Mei-Lan Li, Darryl J. Mar, Damian E. Costello, Daniel K. Nomura, Jen-Chywan Wang*

*Corresponding author. Email: walwang{at}berkeley.edu

This PDF file includes:

  • Fig. S1. Expression analysis of genes involved in ceramide metabolism.
  • Fig. S2. Liver histology and WAT weight in dexamethasone-treated wild-type and Angptl4−/−mice.
  • Fig. S3. PP2A abundance and PKCζ activity in mice infected with adenovirus expressing Ppp2ca shRNA or treated with a PKCζ inhibitor.
  • Table S1. qPCR primer list.

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Technical Details

Format: Adobe Acrobat PDF

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Lipidomic data in the liver and gastrocnemius muscle of control or dexamethasone-treated wild-type and Angptl4−/− mice.

Citation: T.-C. Chen, D. I. Benjamin, T. Kuo, R. A. Lee, M.-L. Li, D. J. Mar, D. E. Costello, D. K. Nomura, J.-C. Wang, The glucocorticoid-Angptl4-ceramide axis induces insulin resistance through PP2A and PKCζ. Sci. Signal. 10, eaai7905 (2017).

© 2017 American Association for the Advancement of Science