Supplementary Materials

Supplementary Materials for:

Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance

Wei Wu, Fubiao Shi, Dianxin Liu, Ryan P. Ceddia, Robert Gaffin, Wan Wei, Huafeng Fang, E. Douglas Lewandowski, Sheila Collins*

*Corresponding author. Email: scollins{at}sbpdiscovery.org

This PDF file includes:

  • Fig. S1. Blood pressures and circulating NP concentrations of Nprc−/−, NprcMKO, and NprcAKO mice.
  • Fig. S2. Expression of Nprc and Npra in skeletal muscle and adipose tissue.
  • Fig. S3. Alternative representation of CLAMS indirect calorimetry data of HFDfed NprcMKO and NprcAKO mice.
  • Fig. S4. HFD-fed NprcAKO and Nprcfl/fl mice show comparable expression of thermogenic-related genes in gWAT and iWAT.
  • Fig. S5. Adipocyte size distribution in iWAT and gWAT of HFD-fed Nprcfl/fl and NprcAKO mice.
  • Fig. S6. NPRC deficiency enhances NP signaling.
  • Table S1. PCR primer sequences.

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Citation: W. Wu, F. Shi, D. Liu, R. P. Ceddia, R. Gaffin, W. Wei, H. Fang, E. D. Lewandowski, S. Collins, Enhancing natriuretic peptide signaling in adipose tissue, but not in muscle, protects against diet-induced obesity and insulin resistance. Sci. Signal. 10, eaam6870 (2017).

© 2017 American Association for the Advancement of Science