Supplementary Materials

Supplementary Materials for:

Bacterial ᴅ-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells

Robert J. Lee,* Benjamin M. Hariri, Derek B. McMahon, Bei Chen, Laurel Doghramji, Nithin D. Adappa, James N. Palmer, David W. Kennedy, Peihua Jiang, Robert F. Margolskee, Noam A. Cohen*

*Corresponding author. Email: rjl{at}mail.med.upenn.edu (R.J.L.); cohenn{at}uphs.upenn.edu (N.A.C.)

This PDF file includes:

  • Fig. S1. Phylogenetic relationship of metabotropic glutamate receptor family proteins.
  • Fig. S2. Antibody validation in transfected HEK293 cells.
  • Fig. S3. Dispersion of PAO-GFP microcolonies in the presence or absence of ᴅ-amino acids.
  • Fig. S4. ᴅ-Amino acids did not affect salt sensitivity of P. aeruginosa strain PAO1.
  • Fig. S5. Sweet ᴅ-amino acids do not affect antibiotic sensitivity of PAO-GFP or ATCC 27853.
  • Fig. S6. ᴅ-Amino acid reduction of mouse nasal SCC T2R–stimulated Ca2+ signals requires T1R3.
  • Table S1. Sequences used for alignment for phylogenetic tree construction.

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Citation: R. J. Lee, B. M. Hariri, D. B. McMahon, B. Chen, L. Doghramji, N. D. Adappa, J. N. Palmer, D. W. Kennedy, P. Jiang, R. F. Margolskee, N. A. Cohen, Bacterial ᴅ-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells. Sci. Signal. 10, eaam7703 (2017).

© 2017 American Association for the Advancement of Science