Supplementary Materials

Supplementary Materials for:

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

Alexander Pyronneau, Qionger He, Jee-Yeon Hwang, Morgan Porch, Anis Contractor, R. Suzanne Zukin*

*Corresponding author. Email: suzanne.zukin{at}einstein.yu.edu

This PDF file includes:

  • Fig. S1. Validation of somatosensory cortex synapse enrichment.
  • Fig. S2. Subcutaneous administration of hydroxypropyl-β-cyclodextrin (vehicle) has little to no effect on cofilin signaling.
  • Fig. S3. Mature Fmr1 KO mice exhibit normal Rac1 signaling at somatosensory cortex synapses.
  • Fig. S4. Mature Fmr1 KO mice exhibit normal cofilin phosphorylation and activity at somatosensory cortex synapses.
  • Table S1. Summary of statistics for Fig. 1.
  • Table S2. Summary of statistics for Fig. 2.
  • Table S3. Summary of statistics for Fig. 3.
  • Table S4. Summary of statistics for Fig. 4.
  • Table S5. Summary of statistics for Fig. 5.
  • Table S6. Summary of statistics for Fig. 6.
  • Table S7. Summary of statistics for fig. S2.
  • Table S8. Summary of statistics for figs. S3 and S4.

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Citation: A. Pyronneau, Q. He, J.-Y. Hwang, M. Porch, A. Contractor, R. S. Zukin, Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome. Sci. Signal. 10, eaan0852 (2017).

© 2017 American Association for the Advancement of Science