Supplementary Materials

Supplementary Materials for:

C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis

Jing Yang,* Zhiqiang Liu, Huan Liu, Jin He, Jianling Yang, Pei Lin, Qiang Wang, Juan Du, Wencai Ma, Zheng Yin, Eric Davis, Robert Z. Orlowski, Jian Hou, Qing Yi*

*Corresponding author. Email: yiq{at}ccf.org (Q.Y.); jiyang{at}mdanderson.org (J.Y.)

This PDF file includes:

  • Fig. S1. Injection of CRP does not affect tumor growth in vivo.
  • Fig. S2. Generation of CRP-expressing myeloma cells.
  • Fig. S3. CRP up-regulates myeloma cell production of cytokines important for OC activation.
  • Fig. S4. Antibodies specific for OC-activating cytokines inhibit CRP-induced OC activation.
  • Fig. S5. Knockdown or overexpression of CD32 does not affect myeloma cell proliferation or survival.
  • Fig. S6. Overexpression of CD32 in myeloma cells enhances CRP-induced OC differentiation.
  • Table S1. Primers used for real-time PCR.

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Citation: J. Yang, Z. Liu, H. Liu, J. He, J. Yang, P. Lin, Q. Wang, J. Du, W. Ma, Z. Yin, E. Davis, R. Z. Orlowski, J. Hou, Q. Yi, C-reactive protein promotes bone destruction in human myeloma through the CD32–p38 MAPK–Twist axis. Sci. Signal. 10, eaan6282 (2017).

© 2017 American Association for the Advancement of Science