Supplementary Materials

Supplementary Materials for:

Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism

John N. Koberstein, Shane G. Poplawski, Mathieu E. Wimmer, Giulia Porcari, Charlly Kao, Bruce Gomes, Davide Risso, Hakon Hakonarson, Nancy R. Zhang, Robert T. Schultz, Ted Abel, Lucia Peixoto*

*Corresponding author. Email: lucia.peixoto{at}wsu.edu

This PDF file includes:

  • Fig. S1. DEScan is a tool to perform differential analysis of data obtained from epigenetic HTS experiments with multiple biological replicates.
  • Fig. S2. Normalization affects detection of differences in chromatin accessibility after learning.
  • Fig. S3. SNP rs6010065 is differentially associated with ASD or intelligence quotient depending on genetic background.
  • Legends for tables S1 and S2
  • Legend for file S1

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Technical Details

Format: Adobe Acrobat PDF

Size: 1.24 MB

Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Detailed annotation of learning-regulated promoters.
  • Table S2 (Microsoft Excel format). Details of which learning-regulated regions are associated with known ASD risk genes.
  • File S1 (.pdf format). DEScan user manual.

[Download Tables S1 and S2]

[Download File S1]


Citation: J. N. Koberstein, S. G. Poplawski, M. E. Wimmer, G. Porcari, C. Kao, B. Gomes, D. Risso, H. Hakonarson, N. R. Zhang, R. T. Schultz, T. Abel, L. Peixoto, Learning-dependent chromatin remodeling highlights noncoding regulatory regions linked to autism. Sci. Signal. 11, eaan6500 (2018).

© 2018 American Association for the Advancement of Science