Supplementary Materials

Supplementary Materials for:

Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel

Lucie Zimova, Viktor Sinica, Anna Kadkova, Lenka Vyklicka, Vlastimil Zima, Ivan Barvik, Viktorie Vlachova*

*Corresponding author. Email: viktorie.vlachova{at}fgu.cas.cz

This PDF file includes:

  • Fig. S1. Mutations in the inner cavity of the sensor module affect chemical-dependent gating of TRPA1.
  • Fig. S2. Average rectification of whole-cell currents through the mutant channels.
  • Fig. S3. Structural comparison with TRPV2 and a central role for Tyr726.
  • Fig. S4. LB-ICS containing Ca2+ abolishes the inhibitory effects of MARCKS and mutant GAP43.
  • Fig. S5. Polar residues in the sensor cavity regulate the activity of TRPA1 under physiological temperatures.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 1.52 MB


Citation: L. Zimova, V. Sinica, A. Kadkova, L. Vyklicka, V. Zima, I. Barvik, V. Vlachova, Intracellular cavity of sensor domain controls allosteric gating of TRPA1 channel. Sci. Signal. 11, eaan8621 (2018).

© 2018 American Association for the Advancement of Science