Supplementary Materials

Supplementary Materials for:

The unfolded protein response regulator ATF6 promotes mesodermal differentiation

Heike Kroeger, Neil Grimsey, Ryan Paxman, Wei-Chieh Chiang, Lars Plate, Ying Jones, Peter X. Shaw, JoAnn Trejo, Stephen H. Tsang, Evan Powers, Jeffery W. Kelly, R. Luke Wiseman, Jonathan H. Lin*

*Corresponding author. Email: jlin{at}

This PDF file includes:

  • Fig. S1. AA147 significantly increases ATF6(N) and GRP78/BiP protein abundance.
  • Fig. S2. AA147 treatment does not affect Wnt, DNA regulation, mRNA surveillance, Fanconi anemia, and cell death signaling pathways in stem cells.
  • Fig. S3. AA147 treatment does not induce mesodermal marker genes in HEK293 cells.
  • Legends for tables S1 to S3
  • Table S4. RNA-seq data set in our transcriptome database.

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Format: Adobe Acrobat PDF

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Summary of genes used in volcano plots.
  • Table S2 (Microsoft Excel format). Raw RNA-seq data.
  • Table S3 (Microsoft Excel format). Comparison study using other cell types and tissues.

Citation: H. Kroeger, N. Grimsey, R. Paxman, W.-C. Chiang, L. Plate, Y. Jones, P. X. Shaw, J. Trejo, S. H. Tsang, E. Powers, J. W. Kelly, R. L. Wiseman, J. H. Lin, The unfolded protein response regulator ATF6 promotes mesodermal differentiation. Sci. Signal. 11, eaan5785 (2018).

© 2018 American Association for the Advancement of Science