Supplementary Materials

Supplementary Materials for:

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis

Jesse Lyons, Douglas K. Brubaker, Phaedra C. Ghazi, Katherine R. Baldwin, Amanda Edwards, Myriam Boukhali, Samantha Dale Strasser, Lucia Suarez-Lopez, Yi-Jang Lin, Vijay Yajnik, Joseph L. Kissil, Wilhelm Haas, Douglas A. Lauffenburger, Kevin M. Haigis*

*Corresponding author. Email: khaigis{at}bidmc.harvard.edu

This PDF file includes:

  • Fig. S1. Histological analysis of colon samples.
  • Fig. S2. Schematic of the experimental design.
  • Fig. S3. Functional annotation of phosphorylation sites for mammalian proteins.
  • Fig. S4. Human PAK1 and PAK2 signaling network neighborhood.
  • Fig. S5. Pak activation during acute colitis.
  • Legends for tables S1 to S9

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Affymetrix microarray quantification of gene expression in individual samples.
  • Table S2 (Microsoft Excel format). MS-based quantification of proteins in individual samples.
  • Table S3 (Microsoft Excel format). MS-based quantification of phosphopeptides in individual samples.
  • Table S4 (Microsoft Excel format). Differential expression analysis for each data set.
  • Table S5 (Microsoft Excel format). Pathway analysis for each data set.
  • Table S6 (Microsoft Excel format). Modules from trans-omics coexpression network analysis.
  • Table S7 (Microsoft Excel format). Statistics for trans-omics coexpression network analysis.
  • Table S8 (Microsoft Excel format). Phosphosite lists for each kinase used in GSEA.
  • Table S9 (Microsoft Excel format). Statistics for GSEA-based kinase enrichment.

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