Supplementary Materials

Supplementary Materials for:

The nociceptin receptor inhibits axonal regeneration and recovery from spinal cord injury

Yuichi Sekine, Chad S. Siegel, Tomoko Sekine-Konno, William B. J. Cafferty, Stephen M. Strittmatter*

*Corresponding author. Email: stephen.strittmatter{at}

This PDF file includes:

  • Fig. S1. NgR1 interacts with ORL1.
  • Fig. S2. ORL1 interacts with NgR1 and NgR2.
  • Fig. S3. Quantification of NgR1 protein in PI-PLC–treated HEK293T cells.
  • Fig. S4. Identification of O-glycosylation sites in NgR1.
  • Fig. S5. Reduction of ORL1 decreases NgR1 expression in Neuro2A and neurons.
  • Fig. S6. Effect of J113397 on nociceptin- and Nogo-mediated inhibition of regeneration.
  • Fig. S7. Motor performance after SCI and J113397 treatment.
  • Fig. S8. Effect of high-dose J113397.
  • Fig. S9. Model for nociception/ORL1-mediated regulation of neural repair in relation to NgR1.
  • Table S1. Gene expression in brainstem after SCI in Ngr1/ and Ngr1+/ mice.

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