Supplementary Materials

Supplementary Materials for:

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer

Galia Maik-Rachline, Elder Zehorai, Tamar Hanoch, John Blenis, Rony Seger*

*Corresponding author. Email: rony.seger{at}weizmann.ac.il

This PDF file includes:

  • Fig. S1. Characterization of the N-terminal p38α domain.
  • Fig. S2. The intracellular distribution of the PERY peptide and its ability to inhibit the stimulation-dependent nuclear translocation of p38β and JNK2.
  • Fig. S3. The PERY peptide inhibits the stimulation-dependent nuclear translocation of p38 in several cancer cell lines.
  • Fig. S4. The PERY peptide does not affect MAPK phosphorylation upon stimulation in several cancer cell lines.
  • Fig. S5. Experimental design for the AOM/DSS-induced cancer model.
  • Fig. S6. The PERY peptide reduces the incidence of AOM/DSS-induced colon cancer.
  • Fig. S7. The PERY peptide reduces tumor load in the AOM/DSS colon cancer model.
  • Fig. S8. The PERY peptide inhibits the stimulation-dependent nuclear translocation of p38α in macrophages.

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