Supplementary Materials

Supplementary Materials for:

Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

Imran Mohammad, Inna Starskaia, Tamas Nagy, Jitao Guo, Emrah Yatkin, Kalervo Väänänen, Wendy T. Watford,* Zhi Chen*

*Corresponding author. Email: watfordw{at}uga.edu (W.T.W.); zchen{at}utu.fi (Z.C.)

This PDF file includes:

  • Fig. S1. Detection of Esr1 deletion or overexpression.
  • Fig. S2. ERα is not essential for T cell development.
  • Fig. S3. ERα deletion within T cells limits colonic inflammation in a murine colitis model.
  • Fig. S4. ERα deletion within T cells limits skin inflammation in a murine T cell transfer model.
  • Fig. S5. Activation of CD4-creERαfl/fl CD4+ T cells and control T cells with a high concentration of anti-CD3 and varying doses of anti-CD28.
  • Fig. S6. Analysis of selected mRNAs in splenocytes.
  • Fig. S7. Oxygen consumption by ERαfl/fl and CD4-creERαfl/fl CD4+ T cells.

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Transcriptomics analysis of gene expression changes in CD4-creERαfl/fl and control CD4+ T cells.

© 2018 American Association for the Advancement of Science