Supplementary Materials

Supplementary Materials for:

A defect in KCa3.1 channel activity limits the ability of CD8+ T cells from cancer patients to infiltrate an adenosine-rich microenvironment

Ameet A. Chimote, Andras Balajthy, Michael J. Arnold, Hannah S. Newton, Peter Hajdu, Julianne Qualtieri, Trisha Wise-Draper, Laura Conforti*

*Corresponding author. Email: laura.conforti{at}

This PDF file includes:

  • Fig. S1. HD and HNSCC CD8+ T cells chemotax toward CXCL12.
  • Fig. S2. KCa3.1 channel blockade inhibits the chemotaxis of HD and HNSCC CD8+ T cells.
  • Fig. S3. Activation of CD8+ T cells from HD and HNSCC patients.
  • Fig. S4. Activation of KCa3.1 channels by NS309 restores the chemotaxis of HNSCC CD8+ T cells in the presence of adenosine.
  • Table S1. Clinicopathologic characteristics of individual HNSCC patients.
  • Table S2. CD8+ T cells from HDs and HNSCC patients chemotax toward CXCL12 similarly.
  • Table S3. Electrophysiological parameters of resting and activated CD8+ T cells isolated from HD and HNSCC patients.

[Download PDF]

© 2018 American Association for the Advancement of Science