Supplementary Materials

Supplementary Materials for:

The interaction between IKKα and LC3 promotes type I interferon production through the TLR9-containing LAPosome

Kachiko Hayashi, Manabu Taura, Akiko Iwasaki*

*Corresponding author. Email: akiko.iwasaki{at}yale.edu

This PDF file includes:

  • Fig. S1. LC3 binds to TLR9 and IKKα after DOTAP–CpG-A stimulation.
  • Fig. S2. ATG5 does not interact with LC3 or IKKα.
  • Fig. S3. LIR mutants of IKKα maintain intact kinase activity.
  • Fig. S4. Fms-related tyrosine kinase 3 ligand–derived Ikkα-deficient pDCs show impaired IFN-α production but intact IL-12p40 after CpG-A stimulation.
  • Fig. S5. WT and LIR-1 but not LIR-2 or LIR-3 mutant IKKα induces IRF7 phosphorylation.
  • Fig. S6. LIR prediction based on IKKβ structure by SWISS-MODEL.

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© 2018 American Association for the Advancement of Science