Supplementary Materials

Supplementary Materials for:

CCR5 adopts three homodimeric conformations that control cell surface delivery

Jun Jin, Fanny Momboisse, Gaelle Boncompain, Florian Koensgen, Zhicheng Zhou, Nelia Cordeiro, Fernando Arenzana-Seisdedos, Franck Perez, Bernard Lagane, Esther Kellenberger, Anne Brelot*

*Corresponding author. Email: anne.brelot{at}pasteur.fr

This PDF file includes:

  • Fig. S1. Cysteine cross-linking identifies TM5 in dimer interfaces.
  • Fig. S2. Lysine mutagenesis destabilizes CCR5 dimer formation without altering receptor folding.
  • Fig. S3. Expression of FLAG-CCR5-KKLV.
  • Fig. S4. MVC favors the transport of CCR5 to the cell surface.
  • Fig. S5. MVC causes a rearrangement of CCR5 TM5.
  • Fig. S6. Residues involved in interprotomer interactions.
  • Fig. S7. MD simulations of the CCR5 monomer when free or in complex with MVC.
  • Fig. S8. Influence of MVC on CCR5 dynamics.
  • Fig. S9. Representative model of the IMVC dimer based on rigid protein-protein docking.
  • Fig. S10. 3D models of the CCR5 covalent dimers obtained by cross-linking with either DSP or BMOE.

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Other Supplementary Material for this manuscript includes the following:


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