Supplementary Materials

Supplementary Materials for:

Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium

Bo Yu, Anuoluwapo Egbejimi, Rachayata Dharmat, Pei Xu, Zhenyang Zhao, Bo Long, Hongyu Miao, Rui Chen, Theodore G. Wensel, Jiyang Cai, Yan Chen*

*Corresponding author. Email: yachen1{at}

This PDF file includes:

  • Fig. S1. Rapamycin-sensitive mTORC1 activation by POS in cultured RPE cells.
  • Fig. S2. POS-induced mTORC1 activation in cultured human fetal RPE cells.
  • Fig. S3. Uptake of latex beads by cultured ARPE-19 cells.
  • Fig. S4. Time course of POS phagocytosis in ARPE-19 cells.
  • Fig. S5. Delayed degradation of ingested POS in RPE cells transfected with siRNAs against KLC1.
  • Fig. S6. POS-stimulated mTORC1 activation in cells with reduced expression of Myo6.
  • Fig. S7. Hypothetical working model of POS-stimulated mTORC1 activation.
  • Table S1. Source of antibodies.

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© 2018 American Association for the Advancement of Science