Supplementary Materials

Supplementary Materials for:

"Disruptor" residues in the regulator of G protein signaling (RGS) R12 subfamily attenuate the inactivation of Gα subunits

Ali Asli, Isra Sadiya, Meirav Avital-Shacham, Mickey Kosloff*

*Corresponding author. Email: kosloff{at}

This PDF file includes:

  • Fig. S1. The RGS interface with Gα subunits is predominantly electrostatic and polar.
  • Fig. S2. A pair of RGS1 and RGS4 residues contributes favorably to electrostatic interactions with the Gα helical domain.
  • Fig. S3. A chimera of RGS14 and RGS16 exhibits increased GAP activity.

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