Supplementary Materials

This PDF file includes:

  • Fig. S1. DCFDA staining of TRX1 knockdown cells and ATM dimerization in PRDX1 and PRDX2 knockout cells.
  • Fig. S2. Additional characterization of the ATM U2OS cell system and replicate experiments with a second ATM shRNA.
  • Fig. S3. ATM C2991L-mutant cells consume more glucose for glycolysis.
  • Fig. S4. ATM C2991L-mutant cells flux more carbon from glucose to the TCA cycle.
  • Fig. S5. ATM C2991L-mutant cells have more total glutathione than WT cells, but GSH/GSSG ratios are similar.
  • Table S1. Sequences of sgRNAs used to knockout PRXD1 or PRDX2 in HeLa cells.

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