Supplementary Materials

This PDF file includes:

  • Fig. S1. XIAP, cIAP1, and cIAP2 in XIAP-knockout cell lines.
  • Fig. S2. L18-MDP–induced NOD2-driven IL6 expression in DC2.4 cell lines.
  • Fig. S3. L18-MDP–induced NOD2 signaling to NF-κB in XIAP-knockout iBMDM cells.
  • Fig. S4. Real-time qPCR of virally expressed XIAP, cIAP1, and cIAP2.
  • Fig. S5. XIAP, cIAP1-XIAP-BIR2, and cIAP2-XIAP-BIR2 in XIAP-knockout cell lines.
  • Fig. S6. Sequence and structure comparison of the RING domains of XIAP, cIAP1, and cIAP2.
  • Fig. S7. XIAP, XIAP-cIAP1-RING, and XIAP-cIAP2-RING in XIAP-knockout cell lines.
  • Fig. S8. Reconstitution of XIAP-knockout HT29 cells with XIAP RING swap variants suppresses cell death.

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