Supplementary Materials

The PDF file includes:

  • Fig. S1. Additional images from live-cell imaging of U2OS cell line.
  • Fig. S2. Results of 500 independent model fits from randomized starting parameters.
  • Fig. S3. Identifiability analysis of model parameter by analysis of likelihood profiles.
  • Fig. S4. Drug response profiles for all chemotherapy and targeted inhibitors predicted by the computational model.
  • Fig. S5. Additional, experimentally measured drug response profiles for chemotherapy and targeted inhibitors.
  • Fig. S6. Western blot data for U2OS and MS-751 cell lines treated with chemotherapies, ATR inhibitor, or combinations.
  • Fig. S7. Additional drug response profiles comparing the potentiating effect of gemcitabine and ATR inhibition between the U2OS cell line and a panel of lung cancer cell lines.
  • Table S1. Quantification of model misfit for individual experimental conditions.
  • Table S2. Chemotherapy drugs and targeted inhibitors used.
  • Table S3. Antibodies used for Western blotting.
  • Legend for movie S1
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mp4 format). Time-lapse video of U2OS cells treated with a combination of gemcitabine and ATR inhibitor.
  • Data file S1 (.pdf format). Model parameters and computational analyses.