Supplementary Materials

This PDF file includes:

  • Fig. S1. Effects of loss of ASIC1a in mice on Asic2a mRNA expression in different brain regions.
  • Fig. S2. Effects of Asic1a gene ablation in mice on basal locomotor activity and motor coordination in a series of behavioral paradigms.
  • Fig. S3. Demonstration of Golgi staining and analysis.
  • Fig. S4. Input-output relationships of AMPAR- and NMDAR-mediated synaptic currents in striatal neurons from WT and Asic1a KO mice.
  • Fig. S5. Effects of loss of ASIC1a on the activation of p38 or JNK signaling in striata.
  • Fig. S6. Effects of acidosis on the phosphorylation of ERK, p38, or JNK in HEK-293 cells.
  • Fig. S7. Effects of pharmacological inhibition of ASIC1a in the striatum on motor learning in the beam walking test.
  • Fig. S8. Representative images showing expression patterns of viral-encoded proteins (represented by EYFP) after AAV-ASIC1a injection into striata of Asic1a KO mice.
  • Fig. S9. Effects of reexpression of ASIC1a in striata of Asic1a null mice on spine density and maturation.
  • Fig. S10. Effects of reexpression of ASIC1a in striata of Asic1a null mice on the performance in the inclined beam walking test.

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