Supplementary Materials

This PDF file includes:

  • Fig. S1. Biochemical analysis of the RIPK3 kinase domain.
  • Fig. S2. Characterization of Ripk3/ MEFs after reconstitution with WT RIPK3 and dimerization-defective RIPK3 mutations.
  • Fig. S3. Expression of RIPK3 V36F does not cause apoptosis or TZ-dependent necroptosis.
  • Fig. S4. Characterization and kinetics of FKBP-FRB RIPK3 fusion system for induced heterodimerization.
  • Fig. S5. RIPK3-induced apoptosis by RIPK3 D161N and the RIPK3 inhibitor GSK′872.
  • Fig. S6. Model of the mechanism of RIPK3 D161N function.

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