Supplementary Materials

This PDF file includes:

  • Fig. S1. HTV injection of TAZ-4SA + NRasV12 constructs increased liver weights in mice.
  • Fig. S2. HTV injection of TAZ constructs increases TAZ abundance in the liver.
  • Fig. S3. TAZ alters expression of CD68 and not VWF in mouse liver tissue.
  • Fig. S4. Mice injected with TAZ-4SA and NRasV12 had inflammatory cell infiltrates in multiple tissues.
  • Fig. S5. Myeloid depletion does not rescue lethality induced by injection with TAZ-4SA + NRasV12.
  • Fig. S6. Phenotypic characterization indicates that TAZ regulates liver inflammation in a TEAD-dependent manner.
  • Fig. S7. Characterization of liver tumor–derived cell lines from mice injected with expression constructs.
  • Fig. S8. Mice injected with 25% TAZ-4SA + NRasV12 constructs developed tumors.
  • Fig. S9. YAP and TAZ drive differential gene expression in liver tumor cells.

[Download PDF]