Supplementary Materials

The PDF file includes:

  • Fig. S1. Relative phosphopeptide abundance between P14 biological replicates.
  • Fig. S2. Relative proliferation in the P1, P7, and P14 cerebellum.
  • Fig. S3. GNP proliferation after CX-4945 treatment in culture.
  • Fig. S4. Knockdown specificity of pooled siRNA constructs targeting Csnk2a1, Csnk2a2, Csnk2b, and Smo.
  • Fig. S5. Gli1 and Hh-associated transcript expression in NIH3T3 cells after CK2 inhibition.
  • Fig. S6. Gli1 transcript expression in cultured SHH MB cell lines.
  • Fig. S7. Weight of control or CX-4945–treated mice with cerebellar SHH MB.
  • Fig. S8. CSNK2A1 expression and 5-year survival of patients with SHH MB.
  • Fig. S9. Sequence conservation of Csnk2a1 mutations in TBB-resistant SHH MB cells.
  • Legends for tables S1 and S2
  • Table S3. Primer and siRNA sequences.
  • Table S4. Pathological report for the primary human MB sample (ST01).

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). Phosphoproteome of GNPs isolated at P1, P7, and P14.
  • Table S2 (Microsoft Excel format). Phosphopeptides of enriched kinase motifs.