Supplementary Materials

This PDF file includes:

  • Fig. S1. Ship2 deletion or knockdown by CRISPR/Cas9 impairs Fgfr3-induced ECM degradation but not cell spreading in RCS cells.
  • Fig. S2. Ship2 deletion or knockdown by CRISPR/Cas9 does not affect Fgfr2 and Fgfr3 abundance in RCS cells.
  • Fig. S3. Deletion or knockdown of Ship2 impairs FGF2-mediated adaptor phosphorylation and activation of Erk.
  • Fig. S4. Densitometric quantifications of Western blot analyses.
  • Fig. S5. No substantial impairment of NGF- or EGF-induced changes in ERK activity in Ship2Crispr cells.
  • Fig. S6. FGFR3 interacts with the SFKs FYN, LYN, FGR, and BLK.
  • Fig. S7. FGR associates with both wild-type and catalytically inactive SHIP2.
  • Fig. S8. Densitometric quantifications of Western blot analyses.
  • Table S1. Expression vectors used in this study.
  • Table S2. Antibodies used in this study.

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