Supplementary Materials

This PDF file includes:

  • Fig. S1. Mitochondrial fission and premature myocardial senescence in peri-infarct zone myocardium after MI.
  • Fig. S2. Changes in protein abundances and activities in peri-infarct zone myocardium after MI.
  • Fig. S3. Mitochondrial morphology in NRCMs.
  • Fig. S4. Reoxygenation-induced mitochondrial ROS production plays an indispensable role in myocardial senescence.
  • Fig. S5. Effects of gene silencing and pharmacological inhibition of Drp1 on mitochondrial morphology and ROS production.
  • Fig. S6. Identification of FLNa by mass spectrometric analysis.
  • Fig. S7. No interaction between Drp1 and the Ig24 dimerization domain of FLNa.
  • Fig. S8. Effect of FLNa knockdown on hypoxia-induced mitochondrial fission and function.
  • Fig. S9. Mitochondrial morphology in cardiac fibroblasts.
  • Fig. S10. Mortality in mice after MI.
  • Table S1. Echocardiographic parameters of mice with cilnidipine administration.
  • Table S2. Cardiac parameters of mice with cilnidipine administration.
  • Table S3. Echocardiographic parameters of Cav2.2(+/+) or Cav2.2(−/−) mice with cilnidipine administration.
  • Table S4. List of Taqman probe and primer sets for real-time PCR.

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