Supplementary Materials

The PDF file includes:

• Fig. S1. Mass spectrometry coverage of c-Cbl and Cbl-b.
• Fig. S2. ICAM-1 coating is consistent between hydrogels of different stiffness.
• Fig. S3. Interaction of CrkL with CasL and c-Cbl.
• Legends for movies S1 to S4

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Other Supplementary Material for this manuscript includes the following:

• Movie S1 (.avi format). WT CD4⁺ T cell migrating on ICAM-1.
• Movie S2 (.avi format). DKO CD4⁺ T cell migrating on ICAM-1.
• Movie S3 (.avi format). Lifeact-GFP–expressing WT CD4⁺ T cell migrating on ICAM-1.
• Movie S4 (.avi format). Lifeact-GFP–expressing DKO CD4⁺ T cell migrating on ICAM-1.