Supplementary Materials

This PDF file includes:

  • Fig. S1. Mn specifically induced inflammasome activation in primary microglial culture.
  • Fig. S2. Mn enhanced LPS-induced nitrite generation.
  • Fig. S3. Mn exposure did not inhibit αSynAgg-induced proinflammatory cytokine production.
  • Fig. S4. Caspase-1-p20–induced cleavage of pro–IL-1β.
  • Fig. S5. Mn exposure inhibited microglial mitochondrial respiration.
  • Fig. S6. LPS increased Mn transporters and Mn uptake.
  • Fig. S7. Mn increased Mul1 expression in a dose-dependent manner.
  • Fig. S8. CRISPR-Cas9 VPS35 KD results in Mfn2 degradation.
  • Fig. S9. Caveolin and clathrin KD reduced Mn-induced Nos2 expression but not TNF-α.
  • Fig. S10. Mn exposure did not change the size distribution of the exosomes secreted by microglial cells.
  • Fig. S11. Exposure to exosomes isolated from Mn-gavaged animals did not alter release of IL-6 and TNF-α.
  • Fig. S12. Mn concentration in whole blood is unaltered in welders.
  • Fig. S13. Proinflammatory cytokine profile of welder and age-matched control populations.

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