Supplementary Materials

This PDF file includes:

  • Fig. S1. MMS treatment results in abnormal RPE structure and topography but not RPE cell loss.
  • Fig. S2. MMS induces overexpression of RIP3 and activation of MLKL in the retina of WT male mice.
  • Fig. S3. MMS treatment induces PARP activation in the PR cells.
  • Fig. S4. Rip3−/− mice show reduced necrosis and no overexpression of proinflammatory markers after MMS treatment.
  • Fig. S5. Treatment with Q-VD-Oph, a pan-caspase inhibitor, does not rescue Rip3−/− male mice from alkylation-induced RD.

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