Supplementary Materials

This PDF file includes:

  • Fig. S1. Enriched expression of GSTT2 in astrocytes in the mouse cerebral cortex.
  • Fig. S2. Enriched expression of GSTM1 in astrocytes in the female mouse brain.
  • Fig. S3. GSTM1 and GSTT2 knockdown efficiency.
  • Fig. S4. No difference in microglia activation in the vicinity of GSTM1 knockdown astrocytes in mice injected with saline.
  • Fig. S5. Reduced activation of microglia during neuroinflammation in mice with astrocyte-specific GSTT2 knockdown.
  • Fig. S6. Representative flow cytometry data of astrocytes used for in vitro cell culture experiments.
  • Fig. S7. Enhanced induction of Tnf expression in BV2 cells cocultured with astrocytes overexpressing GSTM1 or GSTT2.
  • Fig. S8. Total amounts of glutathione in astrocytes treated with different doses of DEM.
  • Table. S1. Primer sequences for qRT-PCR analysis.
  • Table. S2. Statistical analyses used in this manuscript.

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