Supplementary Materials

The PDF file includes:

  • Fig. S1. The second probe trials after extended trainings.
  • Fig. S2. Short-term memory test in object place recognition.
  • Fig. S3. Effects of expressing SHP2D61G in excitatory or inhibitory neurons on basal synaptic transmission and PPF ratio.
  • Fig. S4. Effect of SHP2D61G on ERK activation in PV+ neurons.
  • Fig. S5. The total number of p-ERK1/2+ neurons and viral vector–expressing cells were not significantly different between EYFP- and SHP2D61G-infected hippocampi.
  • Fig. S6. Validation of the quality of cell sorting and bioinformatic workflow.
  • Fig. S7. Comparison of GAB1 protein abundance in vGAT+ and vGAT− neurons in vGAT-Cre;tdTomato mice.
  • Fig. S8. The effect of GAB1Y627F on the interaction of SHP2D61G with GAB1 and ERK activation.
  • Fig. S9. The second probe trials after extended trainings in rescue experiments.
  • Legends for tables S1 to S4

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Other Supplementary Material for this manuscript includes the following:

  • Table S1 (Microsoft Excel format). List of 3482 DEGs.
  • Table S2 (Microsoft Excel format). Functional annotation of 3482 DEGs.
  • Table S3 (Microsoft Excel format). Expression profile of RASopathy-associated genes.
  • Table S4 (Microsoft Excel format). Primer sequences for qRT-PCR validation.