Supplementary Materials

This PDF file includes:

  • Fig. S1. The translocation of β-arrestin2 to the nucleus is dependent on TRPV1 activation and accompanied by a transient PKCβII-dependent phosphorylation of ERK1/2.
  • Fig. S2. Activation of TRPV1 prevents MOR and PAR2 from interacting with β-arrestin2.
  • Fig. S3. The nuclear translocation of β-arrestin2 after TRPV1 stimulation is associated with impaired MOR internalization.
  • Fig. S4. DAMGO and capsaicin have no detectable effects on CaV2.2 inhibition in the absence of MOR and TRPV1.
  • Fig. S5. Peripheral endogenous control of inflammatory pain is absent in female TRPV1-deficient mice.
  • Fig. S6. Paw edema, T lymphocyte infiltration, and opioid production are not altered in TRPV1−/− mice.

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