Supplementary Materials

This PDF file includes:

  • Fig. S1. Ca2+ imaging in hypertrophic and perichondrial cells and pharmacological characterization of Ca2+ fluctuations.
  • Fig. S2. Gene expression analysis and effects of TRPM7 modulators on growth plate chondrocytes.
  • Fig. S3. Conditional knockout of Trpm7.
  • Fig. S4. Effects of PLC and BK channel modulators on naltriben-facilitated Ca2+ fluctuations.
  • Fig. S5. Characterization of facilitated Ca2+ fluctuations under store-depleted conditions.
  • Fig. S6. Gene expression analysis in cultured Trpm7-deficient metatarsal bones.
  • Fig. S7. Effects of CaMKII and CaN inhibitors on cultured metatarsal bones.
  • Fig. S8. Generation and characterization of chondrocyte-specific Trpm7-deficient mice.
  • Fig. S9. Extracellular Mg2+ and cultured Trpm7-deficient bones.
  • Table S1. PCR primers used in the study.

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