Supplementary Materials

The PDF file includes:

  • Text S1. Modeling descriptions.
  • Legends for figures S1 and S2
  • Fig. S3. Chromatin states and RNA-seq data validating TLR5 expression.
  • Fig. S4. Reduced TCR + TLR5 merged model.
  • Fig. S5. Cellular characterization and TLR5 expression in naïve CD4+ T cells.
  • Fig. S6. Comparison of our TCR model with the JSR model.
  • Table S1. BLUEPRINT data used in this study.
  • Table S2. Logical rules for the TCR model.
  • Table S3. Logical rules for the TLR5 model.
  • Table S4. Logical rules for the TCR + TLR5 merged model.
  • Table S5. Global comparison between the JSR model and our model for the TCR signaling network.
  • Table S6. Kruskal-Wallis test results for pp65.
  • Table S7. Kruskal-Wallis test results for pc-Jun.
  • Table S8. Kruskal-Wallis test results for pCREB.
  • Legends for data files S1 to S5

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Other Supplementary Material for this manuscript includes the following:

  • Fig. S1 (.pdf format). TCR molecular map built with the software CellDesigner 4.4.
  • Fig. S2 (.pdf format). TLR5 molecular map built with the software CellDesigner 4.4.
  • Data file S1 (.xml format). TCR molecular map (CellDesigner v4.4).
  • Data file S2 (.zginml format). TCR signaling model (GINsim v3.0b).
  • Data file S3 (.xml format). TLR5 molecular map (CellDesigner v4.4).
  • Data file S4 (.zginml format). TLR5 signaling model (GINsim v3.0b).
  • Data file S5 (.zginml format). TCR + TLR5 merged model (GINsim v3.0b).