Supplementary Materials

The PDF file includes:

  • Fig. S1. Knockout of GR and/or MR is specific to the heart.
  • Fig. S2. Systolic blood pressure in cardioGRKO, cardioMRKO, and cardioGRMRdKO mice.
  • Fig. S3. Histological analysis of cardioGRKO and cardioGRMRdKO hearts.
  • Fig. S4. CardioGRMRdKO mice exhibit RV hypertrophy but no lung edema at 6 months of age.
  • Fig. S5. Genes associated with cardiac pathology are dysregulated in cardioGRMRdKO hearts.
  • Fig. S6. Global gene expression profile in 2-month-old cardioGRKO, cardioMRKO, and cardioGRMRdKO hearts.
  • Fig. S7. Heat maps of differentially expressed genes in the cardioGRKO, cardioMRKO, and cardioGRMRdKO hearts.
  • Fig. S8. Dysregulation of Cell Death and Survival genes in the cardioGRKO, cardioMRKO, and cardioGRMRdKO hearts.
  • Fig. S9. CardioGRMRdKO hearts are protected from the cell death observed in cardioGRKO hearts.
  • Fig. S10. AAV constructs using the Tnnt2 promoter are expressed specifically in cardiomyocytes.
  • Table S1. Electrocardiographic analysis of cardioGRKO, cardioMRKO, and cardioGRMRdKO mice.
  • Table S2. Echocardiography on 3-month-old αMHC-Cre, cardioGRKO, cardioMRKO, and cardioGRMRdKO mice.
  • Table S3. Echocardiography on 1-month-old cardioGRKO mice.
  • Table S4. Echocardiography on 6-month-old αMHC-Cre, cardioGRKO, cardioMRKO, and cardioGRMRdKO mice.
  • Table S5. Echocardiography on cardioGRMRdKO mice injected with AAV-Tnnt2-MR.
  • Legends for data files S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Differentially expressed genes in 1-month cardioGRKO, cardioMRKO, and cardioGRMRdKO hearts.
  • Data file S2 (Microsoft Excel format). Differentially expressed genes in 2-month cardioGRKO, cardioMRKO, and cardioGRMRdKO hearts.