Supplementary Materials

This PDF file includes:

  • Fig. S1. Unchanged expression of Ambn in ORAI-deficient cells.
  • Fig. S2. Enamel cells of Orai1K14 mice do not show increased expression of an unfolded protein response marker.
  • Fig. S3. Normal dental phenotype in ORAI2-deficient mice.
  • Fig. S4. Transduction efficiency in LS8 cells.
  • Fig. S5. Immunofluorescence analysis showing down-regulation of ORAI1 in GFP-positive shOrai1 cells.
  • Fig. S6. Orai1 expression is not significantly altered in shOrai2 cells.
  • Fig. S7. Apoptosis and cell death.
  • Fig. S8. A small Ca2+ leak is present in shOrai1/Orai2 cells.
  • Fig. S9. Increased extracellular acidification rate in shOrai1 cells.
  • Fig. S10. Quantification of velocity (slope) of ER Ca2+ refilling.
  • Table S1. Primers and shRNA sequences used in this study.

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