Supplementary Materials

This PDF file includes:

  • Fig. S1. MCU−/− mice demonstrate postnatal growth retardation.
  • Fig. S2. Inhibition of mitochondrial Ca2+ uptake by MCU siRNA and RU360.
  • Fig. S3. Cell cycle progression is delayed in MCU−/− VSMCs.
  • Fig. S4. Mitochondria in VSMCs with MCU knockdown are fragmented at baseline and do not fragment with PDGF treatment.
  • Fig. S5. PKC activity is not altered in tissues from MCU−/− mice.
  • Fig. S6. CaMKII associates with mitochondria upon PDGF treatment.
  • Fig. S7. PKC inhibition does not alter mitochondrial respiration.
  • Fig. S8. MCU knockdown attenuates the metabolic response to PDGF application.
  • Fig. S9. MCU expression in MCU−/− VSMCs recovers mitochondrial dynamics and respiration.

[Download PDF]