Supplementary Materials
This PDF file includes:
- Fig. S1. Homozygosity for the Irf2 point mutation correlates with low responsiveness to ATP.
- Fig. S2. Irf2splice is a hypomorphic mis-splice mutation.
- Fig. S3. Characterization of Irf2 gRNA KO iMACs.
- Fig. S4. IFNs are dispensable for the attenuation of GSDMD expression.
- Fig. S5. The GSDMD TSS-proximal IRF2 consensus motif is conserved across species.
- Fig. S6. IRF2 motif mutant alleles.
- Fig. S7. Characterization of Irf2−/− BMDMs and mice.
- Fig. S8. Expression of IRF1.
- Table S1. Bioinformatic analysis of ENU-induced SNVs present in IGL03671 pedigree.