Supplementary Materials

This PDF file includes:

• Fig. S1. Homozygosity for the Irf2 point mutation correlates with low responsiveness to ATP.
• Fig. S2. Irf2^splice is a hypomorphic mis-splice mutation.
• Fig. S3. Characterization of Irf2 gRNA KO iMACs.
• Fig. S4. IFNs are dispensable for the attenuation of GSDMD expression.
• Fig. S5. The GSDMD TSS-proximal IRF2 consensus motif is conserved across species.
• Fig. S6. IRF2 motif mutant alleles.
• Fig. S7. Characterization of Irf2^−/− BMDMs and mice.
• Fig. S8. Expression of IRF1.
• Table S1. Bioinformatic analysis of ENU-induced SNVs present in IGL03671 pedigree.

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