Supplementary Materials

This PDF file includes:

  • Fig. S1. Homozygosity for the Irf2 point mutation correlates with low responsiveness to ATP.
  • Fig. S2. Irf2splice is a hypomorphic mis-splice mutation.
  • Fig. S3. Characterization of Irf2 gRNA KO iMACs.
  • Fig. S4. IFNs are dispensable for the attenuation of GSDMD expression.
  • Fig. S5. The GSDMD TSS-proximal IRF2 consensus motif is conserved across species.
  • Fig. S6. IRF2 motif mutant alleles.
  • Fig. S7. Characterization of Irf2−/− BMDMs and mice.
  • Fig. S8. Expression of IRF1.
  • Table S1. Bioinformatic analysis of ENU-induced SNVs present in IGL03671 pedigree.

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