Supplementary Materials

The PDF file includes:

  • Fig. S1. Biomarkers for the differentiation status of H9 cells cultured in Es8 medium.
  • Fig. S2. Biomarkers for the differentiation status of PFX#9 cells cultured in TeSR-E8.
  • Fig. S3. Biomarkers for the differentiation status of PFX#9 cells cultured in mTeSR1.
  • Fig. S4. Exogenous kynurenine partially rescues IDO1 inhibitor–induced suppression of cell proliferation.
  • Fig. S5. Gene expression profiles of mouse Ahr and human AHR.
  • Fig. S6. qRT-PCR scorecard panel for H9 cells under ectoderm induction.
  • Fig. S7. KAT2 inhibition blocks ectodermal differentiation of H9 cells.
  • Fig. S8. Characteristics of EBs.
  • Fig. S9. TGF-β1 and FGF2 positively regulate the transcription of NANOG.
  • Fig. S10. Kynurenic acid (kynurenate) in culture medium.
  • Table S1. Primers used in this study.
  • Table S2. Target metabolites and compounds analyzed by LC-MS/MS.
  • Legends for data files S1 and S2

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Summary of LC-MS/MS data for each figure.
  • Data file S2 (.pdf format). Raw LC-MS/MS data.