Supplementary Materials

This PDF file includes:

  • Fig. S1. KTRs report concentration- and time-dependent CXCR4 signaling in response to FBS.
  • Fig. S2. There is a trend between Akt responsiveness and ERK responsiveness, but initial Akt and ERK activity are poorly correlated with responsiveness in each respective kinase.
  • Fig. S3. CSM for CXCR4 signaling to ERK and Akt.
  • Fig. S4. Differential equations for the three species containing extrinsic noise terms in the computational model.
  • Fig. S5. Extrinsic noise parameters for PI3K, Ras, and mTORC1 produce a highly differentiated signaling landscape of basal activity and CXCR4 responsiveness to ERK and Akt.
  • Fig. S6. Conditional states of cells shift in the context of different conditioning times, stimuli, and genetic mutations.
  • Fig. S7. Computational modeling of responses to the MEK inhibitor trametinib and the mTORC1 inhibitor ridaforolimus shows concentration-dependent, context-specific effects on the activation of Akt and ERK by CXCR4 in MDA-MB-231 cells.
  • Table S1. CSM species descriptions and initial conditions.
  • Table S2. CSM rate equations.
  • Table S3. CSM differential equations.
  • Table S4. CSM parameter values.
  • Table S5. CSM parameters for modeling kinase inhibition.
  • References (6575)

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