Supplementary Materials

The PDF file includes:

  • Text S1. Synthesis of analogs.
  • Fig. S1. Kinase specificity of compounds identified in the GPS-MYC screen.
  • Fig. S2. Inhibition of CDK9 but not CDK8/19 is responsible for MYC loss induced by UNC10112785.
  • Fig. S3. UNC5668 regulation of MYC abundance involves Ser62.
  • Table S1. Structures and cellular activities of UNC10112785 analogs.
  • Legend for data file S1

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Other Supplementary Material for this manuscript includes the following:

  • Data file S1 (Microsoft Excel format). Results from the GPS-MYC screen, with specificity data of PKIS compounds.