Supplementary Materials

This PDF file includes:

  • Fig. S1. The role of LAT in p38 activation in Jurkat T cells and human PBMC CD4+ T cells.
  • Fig. S2. Experimental validation of anti-phospho p38 antisera for pTpY p38 and pY323 p38 detection.
  • Fig. S3. Testing anti-pY323 p38 antibody for pFLOW assay.
  • Fig. S4. Full activation of p38 through the classical pathway is thresholded and time delayed regardless of stimulus strength.
  • Fig. S5. Impact of p38 or MEK1 inhibition on BCR-induced ERK activation.
  • Fig. S6. p38 activation kinetics in primary T cells.
  • Fig. S7. Zap70 expression facilitates p38 activation.
  • Fig. S8. The role of SOS in p38 activation and iTreg formation.
  • Fig. S9. Sos1/2 double deficiency has more substantial impact on iTreg than TH17 cell differentiation.

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