Supplementary Materials

This PDF file includes:

• Fig. S1. Stimulation of hepatocytes with DAG suppresses expression of lipogenic genes.
• Fig. S2. PKD3 deletion is restricted to the liver.
• Fig. S3. Liver-specific PKD3 deletion does not affect metabolism of mice fed an ND.
• Fig. S4. PKD3 does not affect proliferation, immune cell infiltration, or apoptosis in the liver.
• Fig. S5. TG accumulation in the livers of PKD3^liver∆/∆ mice does not depend on FA oxidation or VLDL secretion.
• Fig. S6. The abundance and/or phosphorylation of mTORC1/2 components are not affected by deletion or overexpression of PKD3 in hepatocytes.
• Fig. S7. Quantifications of Western blots of control and PKD3-deficient primary hepatocytes.
• Fig. S8. Quantifications of Western blots of EGFP- and PKD3ca-transduced primary hepatocytes.
• Fig. S9. Liver-specific expression of PKD3ca improves glucose tolerance and insulin sensitivity.
• Table S1. List of antibodies used for Western blotting and immunohistochemistry.
• Table S2. Sequence of primers used for QPCR and genotyping.

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