Supplementary Materials

This PDF file includes:

  • Fig. S1. Expression of TLR7 and TLR8 by human CD14+ monocytes.
  • Fig. S2. TLR7 and TLR8 antagonists do not alter monocyte cytokine expression.
  • Fig. S3. TLR7 and TLR8 blockade alters monocyte cytokine expression after viral infection.
  • Fig. S4. TLR7 and TLR8 knockdown alters monocyte cytokine expression after viral infection.
  • Fig. S5. TLR8 promotes monocyte type I IFN response after viral infection.
  • Fig. S6. TLR7 activation of human monocytes promotes TH17 polarization of CD4+ T cells.
  • Fig. S7. Cytokine expression by TLR7-stimulated monocytes is PI3K independent.
  • Fig. S8. Redundant roles of ATF1, ATF2, and FOSL2 in inducing TH17-type cytokines after TLR7 stimulation.
  • Fig. S9. RNA viruses induce phosphorylation of IRF3 through TLR7 and TLR8 stimulation.
  • Fig. S10. TLR7 and TLR8 stimulation activate IRF5.
  • Fig. S11. Kinetics of IRF3 and IRF7 expression after TLR7 and TLR8 stimulation.
  • Fig. S12. TLR7-dependent inhibition of cytokine expression and type I IFN response is NFAT independent.
  • Fig. S13. Differences between TLR7 and TLR8 signaling in human CD14+ monocytes.

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