Supplementary Materials

This PDF file includes:

  • Fig. S1. Distribution of cancer-associated RGS protein mutations inside and outside the RGS-box.
  • Fig. S2. Distribution of cancer-associated mutations in the RGS-box across different cancer types.
  • Fig. S3. Comparison of GAP potency across the 17 RGS-box proteins tested in yeast.
  • Fig. S4. Effects of representative cancer-associated RGS protein mutations on G protein BRET response amplitudes.
  • Table S1. GAP activities and related features for each of the 49 RGS-box mutants selected for screening in yeast.
  • Table S2. RGS protein quantification by Western blotting analysis.

[Download PDF]